Sport Sciences Research Institute Motor Behavior 2538-273X 7 22 2016 02 20 The effect of systemic administration of insulin on spatial memory and learning in male rats The effect of systemic administration of insulin on spatial memory and learning in male rats 55 70 608 FA Ahmad Rahmani Naser Naghdi Javad Salehi Ali Gorzi Journal Article 2015 02 08 Thus the aim of the current study was to determine whether intraperitoneal (i.p.) administration of insulin improves the water maze motor performance of the rats. Forty male wistar rats were randomly assigned to for groups (each 10 rats). Insulin was injected (0, 1, 6, and 12 U/Kg) once daily for one week. Animals training and testing were conducted using the Morris water maze. Data analyzed using split plot ANOVA (SPANOVA). Results showed significant main effect of time for distance and escape latency in acquisition stage (P<0.001). Also, intraperitoneal injection of insulin, without any significant effect on serum glucose levels, significantly reduced distance moved (P<0.001) and escape latency (P=0.004). Moreover, in retention test, insulin reduced escape latency to hidden platform in a dose dependent manner (dose 12 & 1 U/Kg). Therefore, peripheral administration of insulin has central effects and can enhance motor performance via improvement of spatial learning and memory.  Thus the aim of the current study was to determine whether intraperitoneal (i.p.) administration of insulin improves the water maze motor performance of the rats. Forty male wistar rats were randomly assigned to for groups (each 10 rats). Insulin was injected (0, 1, 6, and 12 U/Kg) once daily for one week. Animals training and testing were conducted using the Morris water maze. Data analyzed using split plot ANOVA (SPANOVA). Results showed significant main effect of time for distance and escape latency in acquisition stage (P<0.001). Also, intraperitoneal injection of insulin, without any significant effect on serum glucose levels, significantly reduced distance moved (P<0.001) and escape latency (P=0.004). Moreover, in retention test, insulin reduced escape latency to hidden platform in a dose dependent manner (dose 12 & 1 U/Kg). Therefore, peripheral administration of insulin has central effects and can enhance motor performance via improvement of spatial learning and memory.  https://mbj.ssrc.ac.ir/article_608_996a7fa078cc36c46d02f9af3bef918b.pdf