Motor Behavior

The Comparison of Immobilization Stress on Learning and Spatial Memory in Young and Old Male Rats

Document Type : Research Paper

Authors

Roya Mirzarazi Dehaghi 1
Shila Safavi Homami 2
Hojjatollah Alaei 3

1 M.Sc. of Motor Behavior, University of Isfahan

2 Assistant Professor of Motor Behavior, University of Isfahan

3 Professor of Physiology, Isfahan University of Medical Sciences

https://doi.org/10.22089/mbj.2018.5438.1632
Abstract
The main purpose of this study was to investigate the effects of immobilization stress on learning and spatial memory between young and old male rats. In order 24 male Wistar rats were selected from Royan institute of Isfahan and divided into 2 age groups based on their weights (3 months= young and 12 months= old). After one week of adaptation to the nest environment, each group (4 groups, n=6) takes part in their special program contains immobility stress group (2h×7days), and sham group. Learning and spatial memory measured by using Morris water maze. Data were analyzed by using independent T-test and two-way variance analyses test. Results showed that immobility stress destroyed learning in young and old rats but had no effect on spatial memory and learning of young rats was less damaged by stress than old rats. The results of this research confirmed the negative effect of immobility stress, especially in learning.

Keywords

Immobilization Stress
Learning
Spatial Memory
Age

Subjects

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Motor Behavior
Volume 10, Issue 32
Summer 2018
Summer 2018
Pages 165-178

  • Receive Date 22 January 2018
  • Revise Date 17 March 2018
  • Accept Date 28 April 2018

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