Document Type : Research Paper
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Abstract
The purpose of this study was to investigate The effect of maternal IntraProtaneal injection of insulin on offspring's’ spatial learning and memory. The research method was experimental. The pregnant Albino-Wistar rats were chosen. The vaginal plug appearance was considered as zero day of pregnancy. insulin injection was started from 1st to 7th day. After lactation (22nd day), the infants were separated from their mothers. Then, the acquisition and spatial memory were evaluated in 56th day in Morris Water Maze. ANOVA and Post-hoc Tukey tests were used to analyze the data. The results suggested that Insulin group had a better performance in both acquisition and spatial memory in Time and distance parameters compared to Salin and control groups (p<0.05). The findings demonstrated that increased insulin of lactation with optimal nutrients may lead to thoroughly development of different systems such as central nervous system. Conclusively, it can be stated that insulin may be effective peripherally in transferring generation effects.
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