Lead (Pb) is a toxic metal that causes clinical disorders in the nervous system. This study was conducted with the aim of evaluating the effect of intermittent exercise and curcumin dietary supplement on cognitive, motor and oxidation indices caused by lead nitrate. In this way, 30 male mice of the Balb C breed (25 ± 5 g) were randomly divided into five groups: negative control (healthy), positive control (lead nitrate), curcumin supplement, High intensity interval training (HIIT) and group High intensity interval training (HIIT) with curcumin. were; High intensity interval training protocol (five sessions per week) was performed for six weeks. After the last training session, the cognitive and motor performance of the animals was evaluated with the Y-maze behavioral test, and 24 hours later, the oxidation indices (SOD, CAT, MDA) and the level of lead in the brain tissue were evaluated. Statistical analysis was done by GraphPad Prism software. The findings showed that after exposure to lead, the motor activity in the positive control group (lead nitrate) decreased compared to the negative control group (healthy) (P=0.01) and the curcumin group (0.01), cognitive performance in All the experimental groups had an increase compared to the lead nitrate group. Taking curcumin along with HIIT decreased the lead level compared to the positive control group (P=0.03). Taking curcumin along with HIIT increased the amount of CAT and SOD in the brain. It was found that the combination of curcumin and HIIT reduce the neurotoxicity caused by lead the inhibition of oxidative stress.