This study examined the effect of Life Kinetic exercises on physical, cognitive, and psychological functions related to falling and fear of falling in patients with multiple sclerosis. An experimental study was conducted on 26 women and 4 men with a mean age of 40.26. The participants were selected through purposive sampling and were randomly assigned to experimental (N = 15) and control (N = 15) groups. The experimental group engaged in Life Kinetik exercises for eight weeks, while the control group participated in stretching and balance exercises. Six-Point Step Test, Short Physical Performance Battery, Wisconsin Card Sorting, Depression-Anxiety-Stress Scale, Multiple Sclerosis Self-Efficacy Scale, and Falls Efficacy Scale-International were used to measure lower limb coordination, dynamic balance, lower limb muscle strength, executive functions, anxiety, depression, self-confidence, and fear of falling, respectively. Analysis of variance with repeated measures (2 × 2) was used to analyze the collected data. A significant difference was found between groups in lower limb coordination, dynamic balance, lower limb muscle strength, executive functions, anxiety, depression, self-confidence, and fear of falling. Therefore, it can be concluded that Life Kinetic exercises were effective in improving lower limb coordination, dynamic balance, lower limb muscle strength, executive functions, self-confidence, and reducing anxiety, depression, and fear of falling. It seems that using Life Kinetic exercises were beneficial. They affected the mind and body, improved physical, cognitive, and psychological functions in patients with multiple sclerosis.