نوع مقاله : مقاله پژوهشی

نویسندگان

1 گروه تربیت بدنی- دانشگاه لرستان، ایران

2 دانشکدۀ تربیت بدنی و علوم ورزشی، دانشگاه خوارزمی تهران، ایران.

چکیده

چکیده
شناسایی عوامل مؤثر بر رشد مهارت‌های حرکتی بنیادی که به‌عنوان زیر‌ساز مهارت‌های حرکتی پیشرفته درنظر گرفته می‌شوند؛ می‌تواند، اهمیت زیادی در شناسایی و هدایت استعداد‌های برتر ورزشی داشته باشد. از اینرو، پژوهش حاضر با هدف بررسی اثر ژنوتیپ‌هایACE وACTN-3 بر رشد مهارت‌های حرکتی بنیادی کودکان انجام شده ‌است. جامعه آماری این پژوهش، شامل کلیه کودکان مهد‌کودکی 4 الی 6 ساله از شهر الشتر بود که به‌شکل تصادفی خوشه‌ای تعداد 50 نفر به‌عنوان نمونۀ پژوهش انتخاب شدند. ابزار گردآوری اطلاعات، شامل آزمون مهارت‌های حرکتی درشت اولریخ- ویرایش دوم و استفاده از PCR جهت تعیین ژنوتیپ‌های ACE و ACTN-3 بود. داده‌های پژوهش با استفاده از آزمون‌ تحلیل واریانس یک‌طرفه و آزمون t مستقل در سطح معناداری P<0.05، مورد تحلیل قرار گرفتند. نتایج نشان داد که کودکان برخوردار از آلل D ژن ACE، (ژنوتیپ DD یا ID)، نسبت ‌به کودکان دارای ژنوتیپ II (P<0.05)، و کودکان برخوردار از آلل R ژن ACTN-3، (ژنوتیپ RR یا RX)، نسبت به کودکان دارای ژنوتیپ XX(P<0.000)، از رشد مهارت‌های حرکتی جابجایی بهتری برخوردار می‌باشند. اما، هیچ‌کدام از این تفاوت‌ها در رشد مهارت‌های حرکتی کنترل ‌شیء (P>0.05)، مشاهده نشد. بنابراین، می‌توان گفت که کودکان برخوردار از ژنوتیپ‌های DD یا ID ژن ACE و ژنوتیپ‌های RR یا RX ژن ACTN-3، از سطح رشدی بالاتری در اجرای مهارت‌های حرکتی جابجایی برخوردارند و در صورت فراهم بودن شرایط محیطی مناسب این افراد در آینده نیز قادر به اجرای مهارت‌های ورزشی در سطوح بالای عملکردی خواهند بود.

کلیدواژه‌ها

عنوان مقاله [English]

The effect of ACE and ACTN-3 difference genotypes on fundamental movement skills development in 4-6 years old children

نویسندگان [English]

  • nazarpouri shahram 1
  • bahram abbas 2

1 Department of Physical Education and Sport Sciences, lorestan University. Iran

2 Faculty of Physical Education and Sport Sciences, Tehran Kharazmi University, Iran.

چکیده [English]

Abstract
The identification of effective factors on fundamental movement skills, considered as the substructure of advanced movement skills, can be very important in superior sports talents’ identification and guidance. Therefore, the aim of this study was to investigate the effect of ACE and ACTN-3 genotypes on the development of fundamental movement skills in children. The statistical population of this study included 4-6 years old kindergarten children in Aleshtar and 50 of them were selected, using cluster sampling method, as the study samples. The data collection tools included the test of gross motor development (TGMD-2) and PCR for determination of ACE and ACTN-3 genotypes. A one-way analysis of variance and independent- t test at a significance level of p≤ 0.05 was used to analyze the study data. The findings showed that the D-allele of ACE carriers, (DD or ID genotype), had greater development of locomotors movement skills than II genotype carriers (p<0/001), and also ACTN-3 R-allele carriers (RR or RX genotype), had greater development of locomotors movement skills than XX genotype (p<0/000). However, none of these differences was observed in the development of object control motor skills (p> 0.05). Therefore, it can be said that the children carrying DD or ID genotype of ACE and RR or RX genotype of ACTN-3 had higher development level in locomotors motor skills performance and will be able to perform sport skills in higher levels if provided with desirable environmental conditions.

کلیدواژه‌ها [English]

  • Key words: "Genotype"
  • "Phenotype"
  • "Sport Gene"
  • "Motor development"
  • "Children"
  1. Branta, C., J. Haubenstricker, and V. Seefeldt, Age changes in motor skills during childhood and adolescence. Exercise and sport sciences reviews, 1984. 12: p. 467-520.
  2. Hardy, L.L., et al., Fundamental movement skills among Australian preschool children. Journal of Science and Medicine in Sport, 2010. 13(5): p. 503-508.
  3. O'keeffe, S., A. Harrison, and P. Smyth, Transfer or specificity? An applied investigation into the relationship between fundamental overarm throwing and related sport skills. Physical Education and Sport Pedagogy, 2007. 12(2): p. 89-102.
  4. Gallahue, D.L., J.C. Ozmun, and J. Goodway, Understanding motor development: Infants, children, adolescents, adults2006: Boston.
  5. Houwen, S., et al., Motor skill performance of schoolage children with visual impairments. Developmental Medicine & Child Neurology, 2008. 50(2): p. 139-145.
  6. Clark, J.E. and J.S. Metcalfe, The mountain of motor development: A metaphor. Motor development: Research and reviews, 2002. 2(163-190).
  7. Payne, V.G. and L.D. Isaacs, Human motor development: A lifespan approach2017: Routledge.
  8. Stodden, D.F., et al., A developmental perspective on the role of motor skill competence in physical activity: An emergent relationship. Quest, 2008. 60(2): p. 290-306.
  9. Collins, M. and M. Posthumus, Genetics and sports2009: Karger Basel.
  10. Malina, R.M., C. Bouchard, and O. Bar-Or, Growth, maturation, and physical activity2004: Human kinetics.
  11. Peeters, M., et al., Heritability of somatotype components: a multivariate analysis. International journal of obesity, 2007. 31(8): p. 1295.
  12. Ellis, L., et al., Is AGT The New Gene For Muscle Performance? An Analysis of AGT, ACTN3, PPARA and IGF2 on Athletic Performance, Muscle Size and Body Fat Percentage in Caucasian Resistance Training Males. Journal of Athletic Enhancement, 2017. 2017.
  13. Bray, M.S., et al., The human gene map for performance and health-related fitness phenotypes: the 2006-2007 update. Medicine and science in sports and exercise, 2009. 41(1): p. 35-73.
  14. Moran, C.N., et al., The associations of ACE polymorphisms with physical, physiological and skill parameters in adolescents. European journal of human genetics, 2006. 14(3): p. 332.
  15. Moran, C.N., et al., Association analysis of the ACTN3 R577X polymorphism and complex quantitative body composition and performance phenotypes in adolescent Greeks. European Journal of Human Genetics, 2007. 15(1): p. 88.
  16. Tobina, T., et al., Association between the angiotensin I-converting enzyme gene insertion/deletion polymorphism and endurance running speed in Japanese runners. The Journal of Physiological Sciences, 2010. 60(5): p. 325-330.
  17. Ahmetov, I.I., et al., The combined impact of metabolic gene polymorphisms on elite endurance athlete status and related phenotypes. Human genetics, 2009. 126(6): p. 751.
  18. Ahmetov, I.I., et al., The association of ACE, ACTN3 and PPARA gene variants with strength phenotypes in middle school-age children. The journal of physiological sciences, 2013. 63(1): p. 79-85.
  19. Erskine, R.M., et al., The individual and combined influence of ACE and ACTN3 genotypes on muscle phenotypes before and after strength training. Scandinavian journal of medicine & science in sports, 2014. 24(4): p. 642-648.
  20. Yang, R., et al., ACTN3 R577X gene variant is associated with muscle-related phenotypes in elite Chinese Sprint/power athletes. The Journal of Strength & Conditioning Research, 2017. 31(4): p. 1107-1115.
  21. Papadimitriou, I.D., et al., ACTN3 R577X and ACE I/D gene variants influence performance in elite sprinters: a multi-cohort study. BMC genomics, 2016. 17(1): p. 285.
  22. Rigat, B., et al., An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. The Journal of clinical investigation, 1990. 86(4): p. 1343-1346.
  23. Reneland, R. and H. Lithell, Angiotensin-converting enzyme in human skeletal muscle. A simple in vitro assay of activity in needle biopsy specimens. Scandinavian journal of clinical and laboratory investigation, 1994. 54(2): p. 105-111.
  24. Gordon, S.E., et al., ANG II is required for optimal overload-induced skeletal muscle hypertrophy. American Journal of Physiology-Endocrinology And Metabolism, 2001. 280(1): p. E150-E159.
  25. Williams, A.G., et al., Circulating angiotensin converting enzyme activity is correlated with muscle strength. Medicine and science in sports and exercise, 2005. 37(6): p. 944-948.
  26. Folland, J., et al., Angiotensin-converting enzyme genotype affects the response of human skeletal muscle to functional overload. Experimental physiology, 2000. 85(5): p. 575-579.
  27. Giaccaglia, V., et al., Interaction between angiotensin converting enzyme insertion/deletion genotype and exercise training on knee extensor strength in older individuals. International journal of sports medicine, 2008. 29(01): p. 40-44.
  28. Pescatello, L.S., et al., ACE ID genotype and the muscle strength and size response to unilateral resistance training. Medicine & Science in Sports & Exercise, 2006. 38(6): p. 1074-1081.
  29. Nazarov, I.B., et al., The angiotensin converting enzyme I/D polymorphism in Russian athletes. European Journal of Human Genetics, 2001. 9(10): p. 797.
  30. Woods, D., et al., Elite swimmers and the D allele of the ACE I/D polymorphism. Human genetics, 2001. 108(3): p. 230-232.
  31. Clarkson, P.M., et al., ACTN3 genotype is associated with increases in muscle strength in response to resistance training in women. Journal of Applied Physiology, 2005. 99(1): p. 154-163.
  32. Charbonneau, D.E., et al., ACE genotype and the muscle hypertrophic and strength responses to strength training. Medicine and science in sports and exercise, 2008. 40(4): p. 677.
  33. Pereira, A., et al., The influence of ACE ID and ACTN3 R577X polymorphisms on lower-extremity function in older women in response to high-speed power training. BMC geriatrics, 2013. 13(1): p. 131.
  34. Scott, R.A., et al., No association between Angiotensin Converting Enzyme (ACE) gene variation and endurance athlete status in Kenyans. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2005. 141(2): p. 169-175.
  35. McCauley, T., et al., Human angiotensinconverting enzyme I/D and αactinin 3 R577X genotypes and muscle functional and contractile properties. Experimental physiology, 2009. 94(1): p. 81-89.
  36. Kim, K., et al., Association of angiotensin converting enzyme I/D and α-actinin-3 R577X genotypes with growth factors and physical fitness in Korean children. The Korean Journal of Physiology & Pharmacology, 2015. 19(2): p. 131-139.
  37. Thomis, M.A., et al., Exploration of myostatin polymorphisms and the angiotensin-converting enzyme insertion/deletion genotype in responses of human muscle to strength training. European journal of applied physiology, 2004. 92(3): p. 267-274.
  38. Coelho, D.B., et al., Angiotensin-converting enzyme (ACE-I/D) polymorphism frequency in Brazilian soccer players. Applied Physiology, Nutrition, and Metabolism, 2016. 41(6): p. 692-694.
  39. Dionísio, T.J., et al., The influence of genetic polymorphisms on performance and cardiac and hemodynamic parameters among Brazilian soccer players. Applied Physiology, Nutrition, and Metabolism, 2017. 42(6): p. 596-604.
  40. North, K.N. and A.H. Beggs, Deficiency of a skeletal muscle isoform of α-actinin (α-actinin-3) in merosin-positive congenital muscular dystrophy. Neuromuscular Disorders, 1996. 6(4): p. 229-235.