نوع مقاله : مقاله پژوهشی
نویسندگان
1 دانشجوی دکتری رشد حرکتی، گروه رفتار حرکتی، دانشکده علوم ورزشی و سلامت، دانشگاه تهران، ایران
2 دانشیار گروه رفتار حرکتی، دانشکده علوم ورزشی و سلامت، دانشگاه تهران، ایران
3 استاد رفتار حرکتی، گروه رفتار حرکتی، دانشکده علوم ورزشی و سلامت، دانشگاه تهران، ایران.
4 استادیار گروه رفتار حرکتی، دانشکده علوم ورزشی و سلامت، دانشگاه تهران، ایران.
5 دانشیار گروه رفتار حرکتی، دانشکده علوم ورزشی و سلامت، دانشگاه تهران، ایران.
چکیده
هدف از مطالعه حاضر تاثیر یک دوره تمرینات هوازی با حجم‌های متفاوت بر BDNF کودکان اوتیسم بود. در این مطالعه نیمه تجربی، 36 کودک 7 تا 10 ساله دچار اختلال اوتیسم شهر تهران به صورت در دسترس برای شرکت در مطالعه حاضر، انتخاب شدند و به صورت تصادفی در سه گروه تمرینات هوازی با حجم بالا، تمرینات هوازی با حجم پایین و کنترل قرار گرفتند. مطالعه شامل مراحل پیش آزمون، مداخله و پس آزمون بود. 24 ساعت قبل و بعد از شروع تمرینات در مرحله پیش آزمون و پس آزمون از شرکت‌کنندگان به صورت ناشتا خونگیری به عمل آمد. مرحله مداخله به مدت پانزده هفته و هر هفته 5 جلسه به طول انجام یافت که گروه‌های مربوطه به تمرینات مربوطه پرداختند و گروه کنترل به اجرای فعالیت‌های معمول و روزانه خود پرداختند. داده‌ها با استفاده از آزمون تی وابسته و تحلیل کوواریانس تک متغیری تحلیل شد. نتایج نشان داد که تمرینات هوازی با حجم بالا بر افزایش BDNF کودکان اوتیسم تاثیر معنی‌داری دارد؛ در حالیکه تمرینات هوازی با حجم پایین بر BDNF کودکان اوتیسم تاثیر معنی‌داری ندارد. به طور کلی نتایج مطالعه حاضر بر اهمیت حجم تمرینات هوازی بر BDNF کودکان اوتیسم تاکید دارد.
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
The effect of a course of aerobic exercises with different volumes on BDNF of autistic children
نویسندگان [English]
- Amin jalali 1
- Fazlolah bagher zadeh 2
- Mahmoud sheikh 3
- mahbobeh ghayour 4
- davoud hominian 5
1 . Ph.D. Students in Motor Development, Department of Motor Behavior, Faculty of Sport Sciences and Health, University of Tehran, Iran
2 Associate Professor in Motor Behavior, Department of Motor Behavior, Faculty of Sport Sciences and Health, University of Tehran, Iran
3 Professor in Motor Behavior, Department of Motor Behavior, Faculty of Sport Sciences and Health, University of Tehran, Iran
4 Assistance Professor in Motor Behavior, Department of Motor Behavior, Faculty of Sport Sciences and Health, University of Tehran, Iran
5 Associate Professor in Motor Behavior, Department of Motor Behavior, Faculty of Sport Sciences and Health, University of Tehran, Iran
چکیده [English]
The purpose of this study was the effect of a course of aerobic exercises with different volumes on BDNF of autistic children. In this semi-experimental study, 36 children from 7 to 10 years old with autism disorder in Tehran were selected as available to participate in the present study, and they were randomly assigned to three groups: aerobic exercise with high volume, aerobic exercise with low volume and control. they got. The study included pre-test, intervention and post-test stages. 24 hours before and after the start of the exercises, in the pre-test and post-test stages, fasting blood was taken from the participants. The intervention phase was carried out for fifteen weeks and 5 sessions each week, where the respective groups did their respective exercises and the control group did their usual daily activities. Data were analyzed using dependent t-test and univariate analysis of covariance. The results showed that high-volume aerobic exercises have a significant effect on the increase of BDNF in children with autism; While aerobic exercise with low volume has no significant effect on BDNF in autistic children. In general, the results of the present study emphasize the importance of the amount of aerobic exercise on the BDNF of autistic children.
کلیدواژه‌ها [English]
- Aerobic exercise
- high volume
- low volume
- BDNF
- autism
- فراهانی، هادی؛ علمیه، علیرضا؛ صمدی، سید علی؛ شعبانی، رامین. (1398). اثر یک دوره آب درمانی بر میزان فاکتور نرون زایی مشتق شده از مغز کودکان دارای اتیسم. مجله علمی پزشکی جندی شاپور، 18(3)، 243-233.
- American Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders (DSM-5). 5th Edn. Arlington, TX: American Psychiatric
- Armeanu, R., Mokkonen, M. & Crespi, B. Meta-analysis of BDNF levels in autism. Cell Mol. Neurobiol. 37, 949–954 (2017).
- Bremer, E., Graham, J. D., Heisz, J. J., & Cairney, J. (2020). Effect of acute exercise on prefrontal oxygenation and inhibitory control among male children with autism spectrum disorder: An exploratory study. Frontiers in Behavioral Neuroscience, 14, 84.
- Bryn, V. et al. Brain derived neurotrophic factor (BDNF) and autism spectrum disorders (ASD) in childhood. Eur. J. Paediatr. Neurol. 19, 411–414 (2015).
- Canton-Martínez, E., Rentería, I., García-Suárez, P. C., Moncada-Jiménez, J., Machado-Parra, J. P., Lira, F. S., ... & Jiménez-Maldonado, A. (2022). Concurrent Training Increases Serum Brain-Derived Neurotrophic Factor in Older Adults Regardless of the Exercise Frequency. Frontiers in Aging Neuroscience, 14.
- Cassilhas, R., Lee, K., Fernandes, J., Oliveira, M., Tufik, S., Meeusen, R., De Mello, M., 2012. Spatial memory is improved by aerobic and resistance exercise through divergent molecular mechanisms. Neuroscience 202, 309–317.
- Davis, C. L., Tomporowski, P. D., Boyle, C. A., Waller, J. L., Miller, P. H., Naglieri, J. A., & Gregoski, M. (2007). Effects of aerobic exercise on overweight children's cognitive functioning: a randomized controlled trial. Research quarterly for exercise and sport, 78(5), 510-519.
- Dinoff, A., Herrmann, N., Swardfager, W., Lanctôt, K.L., 2017. The effect of acute exercise on blood concentrations of brain‐derived neurotrophic factor in healthy adults: a meta‐analysis. Eur. J. Neurosci. 46 (1), 1635–1646.
- Fernandes, B. S. et al. Peripheral brain-derived neurotrophic factor in schizophrenia and the role of antipsychotics: Meta-analysis and implications. Mol. Psychiatry. 20, 1108–1119 (2015).
- Fernandes, J., Arida, R. M., and Gomez-Pinilla, F. (2017). Physical exercise as an epigenetic modulator of brain plasticity and cognition. Neurosci. Biobehav. Rev. 80, 443–456.
- Forti, L. N., Van Roie, E., Njemini, R., Coudyzer, W., Beyer, I., Delecluse, C., et al. (2015). Dose-and gender-specific effects of resistance training on circulating levels of brain derived neurotrophic factor (BDNF) in community-dwelling older adults. Exp. Gerontol. 70, 144–149.
- Francis, K. et al. Brain-derived neurotrophic factor (BDNF) in children with ASD and their parents: A 3-year follow-up. Acta Psychiatr. Scand. 137, 433–441 (2018).
- Fujimura, H., Altar, C. A., Chen, R., Nakamura, T., Nakahashi, T., Kambayashi, J. I., et al. (2002). Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thromb. Haemost. 87, 728–734.
- Gejl, A. K., Enevold, C., Bugge, A., Andersen, M. S., Nielsen, C. H., and Andersen, L. B. (2019). Associations between serum and plasma brain-derived neurotrophic factor and influence of storage time and centrifugation strategy. Sci. Rep. 9:9655.
- Hashimoto, T., Tsukamoto, H., Ando, S., and Ogoh, S. (2021). Effect of exercise on brain health: the potential role of lactate as a myokine. Metabolites 11:813.
- Hatton, D. D. et al. Autistic behavior in children with fragile X syndrome: Prevalence, stability, and the impact of FMRP. Am. J. Med. Genet. A. 140, 1804–1813 (2006).
- Helan, M., Aravamudan, B., Hartman, W.R., Thompson, M.A., Johnson, B.D., Pabelick, C.M., Prakash, Y., 2014. BDNF secretion by human pulmonary artery endothelial cells in response to hypoxia. J. Mol. Cell. Cardiol. 68, 89–97.
- Herold, F., Törpel, A., Schega, L., and Müller, N. G. (2019). Functional and/or structural brain changes in response to resistance exercises and resistance training lead to cognitive improvements - a systematic review. Eur. Rev. Aging Phys. Act. 16, 1–33.
- Hinson, C. (1995). Fitness for children. Champaign, IL: Human Kinetics.
- Huang, Z., Zhang, Y., Zhou, R., Yang, L., and Pan, H. (2021). Lactate as potential mediators for exercise-induced positive effects on neuroplasticity and cerebrovascular plasticity. Front. Physiol. 12:656455.
- Ismail, I., Keating, S.E., Baker, M.K., and Johnson, N.A. 2012. A systematic review and meta-analysis of the effect of aerobic vs. resistance exercise training on visceral fat. Obes. Rev. 13(1): 68–91.
- Jiang, Q., Lou, K., Hou, L., Lu, Y., Sun, L., Tan, S. C., et al. (2020). The effect of resistance training on serum insulin-like growth factor 1(IGF-1): a systematic review and meta-analysis. Complement. Ther. Med. 50:102360.
- Karege, F., Schwald, M. & Cisse, M. Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neurosci. Lett. 328, 261–264 (2002).
- Kasarpalkar, N. J., Kothari, S. T., & Dave, U.P. Brain-derived neurotrophic factor in children with autism spectrum disorder. Ann. Neurosci. 21(2014).
- Meng, W.-D. et al. Elevated serum brain-derived neurotrophic factor (BDNF) but not BDNF gene Val66Met polymorphism is associated with autism spectrum disorders. Mol. Neurobiol. 54, 1167–1172 (2017).
- Miyazaki, K. et al. Serum neurotrophin concentrations in autism and mental retardation: A pilot study. Brain Dev. 20, 292–295 (2004).
- Monnier, A., Prigent‐Tessier, A., Quirié, A., Bertrand, N., Savary, S., Gondcaille, C., et al., 2017. Brain‐derived neurotrophic factor of the cerebral microvasculature: a forgotten and nitric oxide‐dependent contributor of brain‐derived neurotrophic factor in the brain. Acta Physiol. 219 (4), 790–802.
- Northey, J.M., Cherbuin, N., Pumpa, K.L., Smee, D.J., Rattray, B., 2018. Exercise interventions for cognitive function in adults older than 50: a systematic review with meta-analysis. Br. J. Sports Med. 52 (3), 154–160.
- Pinho, R. A., Aguiar, A. S., and Radák, Z. (2019). Effects of resistance exercise on cerebral redox regulation and cognition: an interplay between muscle and brain. Antioxidants 8:529.
- Qin, X.-Y. et al. Association of peripheral blood levels of brain-derived neurotrophic factor with autism spectrum disorder in children: A systematic review and meta-analysis. JAMA Pediatr. 170, 1079–1086 (2016).
- Saghazadeh, A. & Rezaei, N. Brain-derived neurotrophic factor levels in autism: A systematic review and meta-analysis. J. Autism Dev. Disord. 47, 1018–1029 (2017).
- Taurines, R. et al. Altered peripheral BDNF mRNA expression and BDNF protein concentrations in blood of children and adolescents with autism spectrum disorder. J. Neural. Transm. 121, 1117–1128 (2014).
- Turner, L. F., & Turner, S.L. (2000). Ready-to-use pre-sport skills activities program. Paramus, NJ: Parker Publishing Company
- Wagner RE, Zhang Y, Gray T, Abbacchi A, Cormier D, Todorov A, et al. Autism-related variation in reciprocal social behavior: a longitudinal study. Child Dev (2018) 0(0):441–51.
- Walsh, J.J., Bentley, R.F., Gurd, B.J., Tschakovsky, M.E., 2017. Short-duration maximal and long-duration submaximal effort forearm exercise achieve elevations in serum brain-derived neurotrophic factor. Front. Physiol. 8, 746.
- Walsh, J.J., Tschakovsky, M.E., 2018. Exercise and circulating BDNF: mechanisms of release and implications for the design of exercise interventions. Appl. Physiol. Nutr. Metab. 43 (11), 1095–1104.
- Wang, M. et al. Increased serum levels of brain-derived neurotrophic factor in autism spectrum disorder. NeuroReport 26, 638–641 (2015).
- Wass, S. (2011). Distortions and disconnections: disrupted brain connectivity in Brain Cogn. 75, 18–28.
- Wewege, M.A., Thom, J.M., Rye, K.A., and Parmenter, B.J. 2018. Aerobic, resistance or combined training: a systematic review and meta-analysis of exercise to reduce cardiovascular risk in adults with metabolic syndrome. Atherosclerosis, 274: 162–171
- Ye, G., Xiao, Z., Luo, Z., Huang, X., Abdelrahim, M. E. A., and Huang, W. (2021). Resistance training effect on serum insulin-like growth factor 1 in the serum: a meta-analysis. Aging Male 23, 1471–1479.
- Zheng, Z. et al. Peripheral brain-derived neurotrophic factor in autism spectrum disorder: A systematic review and meta-analysis. Sci. Rep. 6, 31241 (2016).
)