نوع مقاله : مقاله پژوهشی

نویسنده

استادیار دانشگاه بین‌المللی امام خمینی (ره)*

چکیده

هدف از این مطالعه، تاثیر تزریق انسولین درون صفاقی در دوران شیردهی مادران بر اکتساب و حافظه فضایی موش-های صحرایی مادر بود. این پژوهش به روش آزمایشگاهی انجام شد. جامعه آماری این پژوهش رت های صحرایی باردار از نژاد آلبینو- ویستار بودند. س از دوران شیردهی (روز بیست ودوم پس از تولد) نوزادان از مادر جدا شدند. سپس در روز 56 رت‌ها برای بررسی و سنجش اکتساب و حافظه فضایی به دستگاه ماز آبی انتقال داده شدند. برای تحلیل داده‌ها از تحلیل واریانس یک طرفه و از آزمون تعقیبی توکی برای تعیین اختلاف میان گروه‌ها استفاده شد. محاسبات آماری از طریق نرم‌افزار آماری SPSS نسخه 20 انجام شده و سطح معنی داری p≤0.05در نظر گرفته شد. نتایج پژوهش نشان داد که گروه انسولین در هر دوی آزمون اکتساب و حافظه فضایی در پارامترهای زمان و مسافت از عملکرد بهتری در مقایسه با دو گروه سالین و کنترل برخوردار بود (P<0.05). نتایج نشان داد افزایش انسولین در دوران شیردهی کیفیت بهتری از شیر مادر را به همراه داشته که این امر می‌تواند رشدوتکامل بهتر سیستم‌های مختلف بدن از جمله سیستم عصبی را به همراه داشته باشید که بهبود اکتساب و یادداری نیز از تبعات احتمالی این اثر می‌باشد. در نتیجه می‌توان اظهار کرد که انسولین می‌تواند بهبود در یادگیری و حافظه فضایی را در انتقال نسل به همراه داشته باشد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effect of IntraProtaneal injection of insulin in lactation period on acquisition and spatial memory of infants

نویسنده [English]

  • Morteza Taheri

چکیده [English]

The purpose of this study was to investigate The effect of maternal IntraProtaneal injection of insulin on offspring's’ spatial learning and memory. The research method was experimental. The pregnant Albino-Wistar rats were chosen. The vaginal plug appearance was considered as zero day of pregnancy. insulin injection was started from 1st to 7th day. After lactation (22nd day), the infants were separated from their mothers. Then, the acquisition and spatial memory were evaluated in 56th day in Morris Water Maze. ANOVA and Post-hoc Tukey tests were used to analyze the data. The results suggested that Insulin group had a better performance in both acquisition and spatial memory in Time and distance parameters compared to Salin and control groups (p<0.05). The findings demonstrated that increased insulin of lactation with optimal nutrients may lead to thoroughly development of different systems such as central nervous system. Conclusively, it can be stated that insulin may be effective peripherally in transferring generation effects.

کلیدواژه‌ها [English]

  • Insulin
  • Acquisition
  • Spatial Memory
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